Recent defeats to Crystal Palace and Manchester United have seen Chelsea’s lead drop from ten points to four.
And while key players Thibaut Courtois and Marcos Alonso missed last weekend’s game at Old Trafford, Gary Cahill has now been ruled out of Saturday’s clash against Spurs at Wembley.
Chelsea will play Southampton about three days after the FA Cup clash, and Conte has admitted that it’s a difficult situation.
“This is a situation very clear for us – we are in trouble. But we are ready,” the Italian said.
“It’s not a simple situation now for us, because you have to consider that you have to play a semi-final in a great competition.
“Then, after two and a half days you have to play against Southampton, and Southampton have rested for 10 days.”