Michy Batshuayi will lead the attack alongside Willian and Eden Hazard in the absence of suspended Pedro and Alvaro Morata.
Chelsea January signing Ross Barkley is on the bench for the first time and could make his Chelsea debut today.
Here are the lineups for both teams:
Brighton starting XI:
Ryan; Schelotto, Duffy, Goldson, Dunk (c), Suttner, Propper, Stephens, March, Gross, Hemed.
Subs: Krul, Hunemeier, Rosenior, Kayal, Izquierdo, Baldock, Murray.
Chelsea starting XI: Caballero, Azpilicueta (c), Christensen, Rudiger, Moses, Bakayoko, Kante, Alonso, Willian, Batshuayi, Hazard.
Subs: Eduardo, Zappacosta, Sterling, David Luiz, Ampadu, Barkley, Musonda.