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Mason Mount was forced off in the first half of the Champions League defeat to Valencia after a late challenge from Francis Coquelin.
Lampard named a 3-4-3 lineup with Mount and Willian supporting Tammy Abraham upfront to complete a front three.
Mount was hit with a nasty tackle inside the first minutes of the game, but he tried to shrug the injury off and continue playing but couldn’t and was eventually subbed off for Pedro who was just returning from injury.
Despite lasting only 15 minutes, Mount had a good game and his impact was badly felt as it took Pedro a bit of time to get into the game.
To make matters worse, Rodrigo went behind the Chelsea defence and struck past Kepa Arrizabalaga at his near post to put the away side in front.
Chelsea bombed forward in search of an equaliser and had the perfect opportunity when VAR ruled in favour of a penalty decision following a handball from Daniel Wass.
Ross Barkley then blasted the penalty against the bar and over and Chelsea’s Champions League dream started with a defeat.
Speaking after the game, Lampard admitted that the substitution disrupted his side’s flow given Mount’s growing influence within the team and that the sub came just too early.
He said: “It did affect it because he started really bright and we know how well he’s playing.
“I thought there were parts of his game that looked really sharp, especially with Willian.
“It was obviously a change you don’t want to make that early.”