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Frank Lampard has decided to stick with a 3-4-3 system that served him well against Tottenham.
The Blues boss has handed rests to Marcos Alonso, Mateo Kovacic and Christian Pulisic.
Chelsea starting XI: Kepa; Rudiger, Zouma, Tomori; Azpilicueta (c), Kante, Jorginho, Emerson; Willian, Abraham, Hudson-Odoi.
Subs: Caballero, Christensen, Barkley, Mount, Pedro, Pulisic, Batshuayi.
Southampton starting XI: McCarthy; Soares, Stephens, Bednarek, Bertrand; Armstrong, Ward-Prowse, Hojbjerg (c), Redmond; Obafemi, Adams
Subs: Gunn, Yoshida, Vestergaard, Romeu, Danso, Boufal, Ings.